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Covance Nonclinical Development Symposium

The combined Covance 23rd NHP symposium with their 9th Annual Biologics symposium to create one, enriching and insightful 2-day educational symposium for nonclinical drug development. Our core topics will be biologics for immuno-oncology, gene therapy and the use of primates in drug development

AGENDA / DIARY for the Nonclinical Symposium

6 May, Wednesday

Development of Biologics in the Immuno-oncology Field

Moderator: Maryland Franklin, Covance

  • Challenges in the nonclinical safety assessment of mAB-based immuno-oncology products (Lolke de Haan, ADC Therapeutics)
  • Separating pharmacology from pathology (Sylvia Guionauad, Guionaud Consulting)
  • Live attentuated arenavirus-based vectors for active cancer immunotherapy (Mohamed Habbeddine, Hookipa)
  • Nonclinical PK/PD and safety evaluation of an anti-ICOS antibody in rats and nonhuman primates (Simon Henderson, Kymab)
  • TBD (Jenny Sims, Integrated Biologix)
  • Roundtable discussion

Development of AAV-Based Gene Therapies

  • Preclinical safety of gene therapies (Basel Assaf, Pfizer)
  • Considerations in the R&D of AAV gene therapies for rare genetic diseases (Page Bouchard, AveXis, a Novartis company)
  • Preclinical development of gene therapeutics and the relevance of NHPs (Joy Cavagnaro, Access Bio)
  • Viral vetor development: concepts, technologies and challenges (Christian Thirion, Sirion Biotech)
  • Roundtable discussion

7 May, Thursday

Keynote Lecture

  • Background Diseases in Cynomolgus and Marmoset Delivery (Keith Mansfield, Novartis: Background infections in nonhuman primates)

The Use of Nonhuman Primates in Drug Development

  • TBD (Jorg Blumel, Genentech)
  • Use of NHP to charactertize safety of RNA splice modifiers such as risdiplam for rare human disease (Lutz Muller, Roche)
  • Immune profiling of Mauritian and Cambodian (Asia) cynomolgus monkeys by flow cytometry and understanding immunological response to ASOs (Padma Narayanan, Johnson & Johnson)
  • Global primate procurement and the recent changes in demand versus supply (Steve Owen, Envigo)
  • Opportunities to apply the 3Rs within NHP toxicology programmes (Helen Prior, NC3R)
  • Roundtable discussion

Cost: 150 Euros

Location: Germany

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