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Photo from unsplash / @Halacious
Photo from unsplash / @Halacious

Biopeople network member ISD Immunotech enters strategic research collaboration for the development of a novel lupus treatment


Severe Systemic Lupus Erythematosis is a disease for which current therapeutic options are few, unsafe or ineffective. ISD Immunotech (ISD), which is developing targeted therapies for severe autoimmune diseases, today announces it has entered into a strategic research collaboration with Biogen Inc., Cambridge, MA, USA (Nasdaq: BIIB).

ISD and Biogen will work together to develop ISD's lead compound, ISD 017, which is being developed to treat severe lupus - systemic lupus erythematosus (SLE). Severe lupus is an autoimmune disease that can damage many parts of the body, including the joints, skin, kidneys, heart, lungs, blood vessels and brain, which if left untreated can lead to kidney failure and cardiovascular mortality. There are up to 1.5 million people in the US alone with lupus. ISD 017 is a proprietary and novel peptide therapeutic which is an inhibitor of the stimulator of interferon genes (STING) pathway. The STING pathway has recently been shown to play a central role and to be overactivated in severe lupus, a condition with a highly underserved patient population.

"We are pleased that Biogen, a leader in drug development has selected ISD Immunotech as its collaboration partner. With its recent positive Phase 2 study results for CLE and SLE, Biogen's interests and competencies complement ISD Immunotech's areas of expertise in lupus, STING biology and peptide drug development," said Tara Heitner, CEO of ISD Immunotech. "This collaboration underscores the quality of our therapeutic program and recognizes the importance of STING pathway overactivation in severe SLE. Together with Biogen, we aim to deliver one of the first new therapies to treat severe SLE in over 50 years."

Read more about ISD Immunotech on their homepage here.

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